Projects per year
Abstract
Background: Hypertension is related to autonomic nervous system(ANS) dysfunction, atherosclerosis and chronic inflammation. The stimulation of baroreflex regulation by slow-breathing exercise may improve the interplay among these systems. The objective of this study was to investigate the effect of device-guided slow breathing on ANS, cardiovascular system and chronic inflammation in hypertensive patients. Methods: We prospectively collected 36 essential hypertension patients who were requested to practice slowbreathing exercise 5 times per day for 3 months. The breathing exercise was guided by a cellphone app with a wearable electrocardiography device and a rhythm of 6 cycles per minute. Cardiovascular indicators including heart rate variability (HRV), blood pressure, pulse wave velocity and baroreflex indexes were sampled 3 times: at the first visit, and 1 month and 3 months after the intervention. The levels of blood inflammatory biomarkers, including tumor necrosis factor-alpha (TNF-α), interleukin-6, interleukin-1 receptor antagonist and C-reactive protein were also collected at all 3 visits. The longitudinal differences in these variables and their correlationswere tested. Results: There was a significant decrease in blood pressure after 1 month of exercise. A significantly continuous decrease in TNF-α was also observed. The baroreflex indexes were significantly increased in the acute intervention of slow-breathing but not in the longitudinal effect. The HRV variables did not show differences with time. There were positive correlations between sympathetic index and TNF--α and galectin-3. Conclusions: The effect of slow-breathing exercise on blood pressure and chronic inflammation was significant. HRV indexes may also be used to assess chronic inflammation.
Original language | English |
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Pages (from-to) | 195-203 |
Number of pages | 9 |
Journal | Acta Cardiologica Sinica |
Volume | 37 |
Issue number | 2 |
DOIs | |
State | Published - 2021 |
Keywords
- Atherosclerosis
- Autonomic function
- Baroreflex
- Chronic inflammation
- Hypertension
- Slow breathing
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Dive into the research topics of 'Long-term effect of device-guided slow breathing on blood pressure regulation and chronic inflammation in patients with essential hypertension using a wearable ECG device'. Together they form a unique fingerprint.Projects
- 4 Finished
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A Multi-Signal Based Automated Monitoring System for Pediatric Sleep Disorders(2/2)
1/08/20 → 31/07/21
Project: Research
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Intelligent Autoguiding Otoscope and Image Classification System-Home-Based Screening for Otitis Media
1/11/18 → 31/10/19
Project: Research