Lifetime of ligand-receptor clusters under external force

Chih Chao Tang, Yi Ping Chu, Hsuan Yi Chen

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7 Scopus citations


We present a theory for the lifetime T (N,f) of a ligand-receptor cluster with N bonds under constant external force F=fN, where f is force per bond. We show that there exists a critical force per bond fc such that at large N when f> fc the lifetime T (N,f) is independent of cluster size N; when f< fc the lifetime scales as ln [T (N,f)] ∼N due to a free energy barrier with height ∼N along the dissociation path; when f= fc, the lifetime scales as T (N,f) ∼ N1 3 due to strong fluctuation of a number of closed bonds. Our study shows that adhesion clusters with more bonds are more stable at small f but respond to external force as fast as smaller adhesion clusters at large f.

Original languageEnglish
Article number061905
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Issue number6
StatePublished - 10 Dec 2007


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