TY - JOUR

T1 - Lifetime of ligand-receptor clusters under external force

AU - Tang, Chih Chao

AU - Chu, Yi Ping

AU - Chen, Hsuan Yi

PY - 2007/12/10

Y1 - 2007/12/10

N2 - We present a theory for the lifetime T (N,f) of a ligand-receptor cluster with N bonds under constant external force F=fN, where f is force per bond. We show that there exists a critical force per bond fc such that at large N when f> fc the lifetime T (N,f) is independent of cluster size N; when f< fc the lifetime scales as ln [T (N,f)] ∼N due to a free energy barrier with height ∼N along the dissociation path; when f= fc, the lifetime scales as T (N,f) ∼ N1 3 due to strong fluctuation of a number of closed bonds. Our study shows that adhesion clusters with more bonds are more stable at small f but respond to external force as fast as smaller adhesion clusters at large f.

AB - We present a theory for the lifetime T (N,f) of a ligand-receptor cluster with N bonds under constant external force F=fN, where f is force per bond. We show that there exists a critical force per bond fc such that at large N when f> fc the lifetime T (N,f) is independent of cluster size N; when f< fc the lifetime scales as ln [T (N,f)] ∼N due to a free energy barrier with height ∼N along the dissociation path; when f= fc, the lifetime scales as T (N,f) ∼ N1 3 due to strong fluctuation of a number of closed bonds. Our study shows that adhesion clusters with more bonds are more stable at small f but respond to external force as fast as smaller adhesion clusters at large f.

UR - http://www.scopus.com/inward/record.url?scp=37049011021&partnerID=8YFLogxK

U2 - 10.1103/PhysRevE.76.061905

DO - 10.1103/PhysRevE.76.061905

M3 - 期刊論文

C2 - 18233867

AN - SCOPUS:37049011021

VL - 76

JO - Physical Review E - Statistical, Nonlinear, and Soft Matter Physics

JF - Physical Review E - Statistical, Nonlinear, and Soft Matter Physics

SN - 1539-3755

IS - 6

M1 - 061905

ER -