Lewis acid-catalyzed cleavage of carbamate and carbonate resins

Wen Ren Li, Yu Sheng Lin, Ying Chih Yo

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


A procedure for the preparation of amides and esters on a Merrifield resin-bound benzyloxycarbonyl equivalent has been developed. Polymer-supported carbamates react cleanly with zinc bromide and the appropriate acyl halide in the presence of triethylamine to provide their corresponding amides in high yields and purities. Cleavage of resin-bound carbonates was carried out using the similar reagent systems in the absence of triethylamine to give acetates or benzoates.

Original languageEnglish
Pages (from-to)6619-6622
Number of pages4
JournalTetrahedron Letters
Issue number34
StatePublished - 19 Aug 2000


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