Kinetics and morphology analysis for fabrication a mimetic bio-membrane on Brij-76 derived surface

Liang Yu Chen, Jia Jia Lin, Ming Shen Lin, Shiu Mei Chiu, Yung Chang, Wen Yih Chen

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

We investigated the effects of the phosphoglycerides (l-α-dipalmitoyl-phosphatidylcholine (DPPC) and lecithin (egg PC)) and cholesterol contents of liposome on the topographies and the kinetics deposition mechanisms on the polyethylene glycol ocatadecyl ether (Brij-76) derived solid surface by (1) the morphology analysis of atomic force microscopy and (2) the real-time monitoring of quartz crystal microbalance sensor. The DPPC-LUVs depositions were the major vesicular lipid bilayer on the surface, while the deposited egg PC-LUVs formed the planar lipid bilayer. The roles of phosphoglycerides and the cholesterol contents in the mechanism and the conformation of lipid vesicles onto the surface were discussed.

Original languageEnglish
Pages (from-to)86-91
Number of pages6
JournalColloids and Surfaces A: Physicochemical and Engineering Aspects
Volume296
Issue number1-3
DOIs
StatePublished - 15 Mar 2007

Keywords

  • Cholesterol
  • DPPC
  • Egg PC
  • Kinetics
  • Liposome
  • Morphology
  • Sensor

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