Investigation of Neurological Complications after COVID-19 Vaccination: Report of the Clinical Scenarios and Review of the Literature

Wei Ping Chen, Ming Hua Chen, Shih Ta Shang, Yung Hsi Kao, Kuo An Wu, Wen Fang Chiang, Jenq Shyong Chan, Hann Yeh Shyu, Po Jen Hsiao

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), broke out in 2019 and became a pandemic in 2020. Since then, vaccines have been approved to prevent severe illness. However, vaccines are associated with the risk of neurological complications ranging from mild to severe. Severe complications such as vaccine-induced immune thrombotic thrombocytopenia (VITT) associated with acute ischaemic stroke have been reported as rare complications post-COVID-19 vaccination. During the pandemic era, VITT evaluation is needed in cases with a history of vaccination within the last month prior to the event. Cerebral venous sinus thrombosis (CVST) should be suspected in patients following immunization with persistent headaches who are unresponsive to analgesics. In this article, we investigated neurological complications after COVID-19 vaccination and provided more subsequent related clinical studies of accurate diagnosis, pathophysiological mechanisms, incidence, outcome, and management.

Original languageEnglish
Article number425
JournalVaccines
Volume11
Issue number2
DOIs
StatePublished - Feb 2023

Keywords

  • Bell’s palsy
  • COVID-19 vaccines
  • Guillain—Barré syndrome
  • cerebral venous sinus thrombosis
  • neurological complications
  • postvaccinal meningitis and encephalitis
  • transverse myelitis
  • vaccine-associated herpes simplex encephalitis

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