TY - JOUR
T1 - Initial solvent screening of
T2 - Carbamazepine, cimetidine, and phenylbutazone: Part 2 of 2
AU - Lee, Tu
AU - Su, Yan Chan
AU - Hou, Hung Ju
AU - Hsieh, Hsiang Yu
PY - 2009/6
Y1 - 2009/6
N2 - Many processes such as spherical crystallization, microemulsions, and organic nanocrystal fabrication require combinations of several solvents. A solution's composition ratio at the time of nucleation greatly influences the solubility, polymorphism, and crystal habits of crystals of active pharmaceutical ingredients. The literature, however, provides little advice for identifying the best solvent combinations. The authors describe the importance of a rapid and an abbreviated screening strategy in initial solvent screening.
AB - Many processes such as spherical crystallization, microemulsions, and organic nanocrystal fabrication require combinations of several solvents. A solution's composition ratio at the time of nucleation greatly influences the solubility, polymorphism, and crystal habits of crystals of active pharmaceutical ingredients. The literature, however, provides little advice for identifying the best solvent combinations. The authors describe the importance of a rapid and an abbreviated screening strategy in initial solvent screening.
UR - http://www.scopus.com/inward/record.url?scp=77952065883&partnerID=8YFLogxK
M3 - 期刊論文
AN - SCOPUS:77952065883
SN - 1543-2521
VL - 33
SP - 54
EP - 61
JO - Pharmaceutical Technology
JF - Pharmaceutical Technology
IS - 6
ER -