Inference about binocular sensitivity and specificity of screening tests for paired organs

Tsung Shan Tsou, Wei Cheng Hsiao

Research output: Contribution to journalArticlepeer-review


Recently Perera et al. introduced two new binocular accuracy measures to evaluate diagnostic tests for paired organs. They adopted the Gaussian copula model to account for correlation between fellow eyes. As the measures are functions of several joint probabilities and due to the nature of the joint models, variations of the estimates for the two new measures were assessed via bootstrapping. We provide a different approach to inference about the two interesting and innovative measures. In our opinion, when patients are independent, the binomial models suffice for inference about the parameters of interest. Inference becomes simple and straightforward. We perform numerical studies and analyse the data set as of Perera et al. for illustration. Also, we investigate thru simulations the issue of robustness of the Gaussian copula and the binomial models under model misspecification.

Original languageEnglish
Pages (from-to)1950-1959
Number of pages10
JournalStatistical Methods in Medical Research
Issue number7
StatePublished - 1 Jul 2020


  • binocular sensitivity
  • binocular specificity
  • Gaussian copula
  • Ophthalmology
  • pairing


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