Induction of G0/G1 arrest and apoptosis by 3-hydroxycinnamic acid in human cervix epithelial carcinoma (HeLa) cells

Jing Yuan Chuang; Yueh Yu Tsai; Ssu Ching Chen; Tian Jye Hsieh; Jing Gung Chung

Induction of G₀/G₁ arrest and apoptosis by 3-hydroxycinnamic acid in human cervix epithelial carcinoma (HeLa) cells

Jing Yuan Chuang, Yueh Yu Tsai, Ssu Ching Chen, Tian Jye Hsieh, Jing Gung Chung

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

The present studies were undertaken to analyze the factors regulating 3-hydroxycinnamic acid-induced apoptosis and cell cycle arrest. Treatment of human cervix HeLa cells with 3-hydroxycinnamic acid induced apoptosis and G₀/G₁-phase arrest. The percentage of apoptosis induced by 3-hydroxycinnamic acid in HeLa cells was increased with incubation time. The results also demonstrated that 3-hydroxycinnamic acid increased the expression of p53, caspase-3, Bax and cyclin B. These results demonstrated that 3-hydroxycinnamic acid induced apoptosis through p53- and caspase-3-dependent pathways.

Original language	English
Pages (from-to)	683-688
Number of pages	6
Journal	In Vivo
Volume	19
Issue number	4
State	Published - 2005

Keywords

3-Hydroxycinnamic acid
Cell cycle
G/G arrest

Cite this

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title = "Induction of G0/G1 arrest and apoptosis by 3-hydroxycinnamic acid in human cervix epithelial carcinoma (HeLa) cells",

abstract = "The present studies were undertaken to analyze the factors regulating 3-hydroxycinnamic acid-induced apoptosis and cell cycle arrest. Treatment of human cervix HeLa cells with 3-hydroxycinnamic acid induced apoptosis and G0/G1-phase arrest. The percentage of apoptosis induced by 3-hydroxycinnamic acid in HeLa cells was increased with incubation time. The results also demonstrated that 3-hydroxycinnamic acid increased the expression of p53, caspase-3, Bax and cyclin B. These results demonstrated that 3-hydroxycinnamic acid induced apoptosis through p53- and caspase-3-dependent pathways.",

keywords = "3-Hydroxycinnamic acid, Cell cycle, G/G arrest",

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T1 - Induction of G0/G1 arrest and apoptosis by 3-hydroxycinnamic acid in human cervix epithelial carcinoma (HeLa) cells

AU - Chuang, Jing Yuan

AU - Tsai, Yueh Yu

AU - Chen, Ssu Ching

AU - Hsieh, Tian Jye

AU - Chung, Jing Gung

PY - 2005

Y1 - 2005

N2 - The present studies were undertaken to analyze the factors regulating 3-hydroxycinnamic acid-induced apoptosis and cell cycle arrest. Treatment of human cervix HeLa cells with 3-hydroxycinnamic acid induced apoptosis and G0/G1-phase arrest. The percentage of apoptosis induced by 3-hydroxycinnamic acid in HeLa cells was increased with incubation time. The results also demonstrated that 3-hydroxycinnamic acid increased the expression of p53, caspase-3, Bax and cyclin B. These results demonstrated that 3-hydroxycinnamic acid induced apoptosis through p53- and caspase-3-dependent pathways.

AB - The present studies were undertaken to analyze the factors regulating 3-hydroxycinnamic acid-induced apoptosis and cell cycle arrest. Treatment of human cervix HeLa cells with 3-hydroxycinnamic acid induced apoptosis and G0/G1-phase arrest. The percentage of apoptosis induced by 3-hydroxycinnamic acid in HeLa cells was increased with incubation time. The results also demonstrated that 3-hydroxycinnamic acid increased the expression of p53, caspase-3, Bax and cyclin B. These results demonstrated that 3-hydroxycinnamic acid induced apoptosis through p53- and caspase-3-dependent pathways.

KW - 3-Hydroxycinnamic acid

KW - Cell cycle

KW - G/G arrest

UR - http://www.scopus.com/inward/record.url?scp=21344442191&partnerID=8YFLogxK

M3 - 期刊論文

C2 - 15999534

AN - SCOPUS:21344442191

SN - 0258-851X

VL - 19

SP - 683

EP - 688

JO - In Vivo

JF - In Vivo

IS - 4

ER -

Induction of G0/G1 arrest and apoptosis by 3-hydroxycinnamic acid in human cervix epithelial carcinoma (HeLa) cells

Abstract

Keywords

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Induction of G₀/G₁ arrest and apoptosis by 3-hydroxycinnamic acid in human cervix epithelial carcinoma (HeLa) cells