In Vivo Validation of Diffuse Optical Imaging with a Dual-Direction Measuring Module of Parallel-Plate Architecture for Breast Tumor Detection

Jhao Ming Yu, Liang Yu Chen, Min Cheng Pan, Ya Fen Hsu, Min Chun Pan, Yi Ling Lin, Sheng Yih Sun, Chia Cheng Chou

Research output: Contribution to journalArticlepeer-review

Abstract

We demonstrate a working prototype of an optical breast imaging system involving parallel-plate architecture and a dual-direction scanning scheme designed in combination with a mammography machine; this system was validated in a pilot study to demonstrate its application in imaging healthy and malignant breasts in a clinical environment. The components and modules of the self-developed imaging system are demonstrated and explained, including its measuring architecture, scanning mechanism, and system calibration, and the reconstruction algorithm is presented. Additionally, the evaluation of feature indices that succinctly demonstrate the corresponding trans-mission measurements may provide insight into the existence of malignant tissue. Moreover, five cases are presented including one subject without disease (a control measure), one benign case, one suspected case, one invasive ductal carcinoma, and one positive case without follow-up treatment. A region-of-interest analysis demonstrated significant differences in absorption between healthy and malignant breasts, revealing the average contrast between the abnormalities and background tissue to exceed 1.4. Except for ringing artifacts, the average scattering property of the structure densities was 0.65–0.85 mm−1.

Original languageEnglish
Article number1040
JournalBiomedicines
Volume10
Issue number5
DOIs
StatePublished - May 2022

Keywords

  • diffuse optical imaging
  • dual-direction scanning
  • feature index
  • optical breast imaging system

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