In vivo sampling of extracellular β-thymosin by ultrafiltration probes

Yu Tsueng Liu, Chun Ming Huang

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

4 Scopus citations

Abstract

In vivo detection and monitoring of extracellular β-thymosin will facilitate the understanding of their biological function and association with disease progression. A novel technique using capillary ultrafiltration (CUF) probes linked to mass spectrometry is capable of sensing extracellular thymosin β-4 and/or thymosin β-10 in vivo in wounded skin and other tissue microenvironments. In this review, we highlight the association of extracellular β-thymosin with skin wound healing and the potential adjuvant effects on vaccination. The fabrication and biological application of CUF probes are also described. Data from CUF probe-captured β-thymosin may guide future exploration of extracellular β-thymosin.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
PublisherBlackwell Publishing Inc.
Pages104-113
Number of pages10
ISBN (Print)1573317012, 9781573317016
DOIs
StatePublished - Sep 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1112
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Extracellular
  • In vivo sampling
  • Mass spectrometry
  • Ultrafiltration probe
  • β-thymosin

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