Hydrodynamics of stratified epithelium: Steady state and linearized dynamics

Wei Ting Yeh, Hsuan Yi Chen

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

A theoretical model for stratified epithelium is presented. The viscoelastic properties of the tissue are assumed to be dependent on the spatial distribution of proliferative and differentiated cells. Based on this assumption, a hydrodynamic description of tissue dynamics at the long-wavelength, long-time limit is developed, and the analysis reveals important insights into the dynamics of an epithelium close to its steady state. When the proliferative cells occupy a thin region close to the basal membrane, the relaxation rate towards the steady state is enhanced by cell division and cell apoptosis. On the other hand, when the region where proliferative cells reside becomes sufficiently thick, a flow induced by cell apoptosis close to the apical surface enhances small perturbations. This destabilizing mechanism is general for continuous self-renewal multilayered tissues; it could be related to the origin of certain tissue morphology, tumor growth, and the development pattern.

Original languageEnglish
Article number052421
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume93
Issue number5
DOIs
StatePublished - 31 May 2016

Fingerprint

Dive into the research topics of 'Hydrodynamics of stratified epithelium: Steady state and linearized dynamics'. Together they form a unique fingerprint.

Cite this