High Sensitivity and High Detection Specificity of Gold-Nanoparticle-Grafted Nanostructured Silicon Mass Spectrometry for Glucose Analysis

Chia Wen Tsao, Zhi Jie Yang

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

Desorption/ionization on silicon (DIOS) is a high-performance matrix-free mass spectrometry (MS) analysis method that involves using silicon nanostructures as a matrix for MS desorption/ionization. In this study, gold nanoparticles grafted onto a nanostructured silicon (AuNPs-nSi) surface were demonstrated as a DIOS-MS analysis approach with high sensitivity and high detection specificity for glucose detection. A glucose sample deposited on the AuNPs-nSi surface was directly catalyzed to negatively charged gluconic acid molecules on a single AuNPs-nSi chip for MS analysis. The AuNPs-nSi surface was fabricated using two electroless deposition steps and one electroless etching step. The effects of the electroless fabrication parameters on the glucose detection efficiency were evaluated. Practical application of AuNPs-nSi MS glucose analysis in urine samples was also demonstrated in this study.

Original languageEnglish
Pages (from-to)22630-22637
Number of pages8
JournalACS Applied Materials and Interfaces
Volume7
Issue number40
DOIs
StatePublished - 14 Oct 2015

Keywords

  • desorption/ionization on silicon
  • glucose analysis
  • mass spectrometry
  • matrix-free laser desorption/ionization
  • nanostructured silicon

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