Hemocompatible interface control via thermal-activated bio-inspired surface PEGylation

Mei Chan Sin, Wen Lin Lin, Jeff Chang Hung Chen, Akon Higuchi, Jie Zheng, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Yung Chang

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

A facile thermal-activated self-copolymerization coating of antifouling layers was designed. PEGylated poly(ethyleneimine) (PEI-PEGMA) was first synthesized, mixed with an alkaline dopamine solution, and then concurrently codeposited onto versatile substrates of both organic and inorganic materials. Thermal-activated codeposition of dopamine/PEI-PEGMA could then proceed, giving rise to good hemocompatible performance in respect to low fibrinogen adsorption, ultra-low blood cell adhesion and activation, and almost undetectable hemolytic activities. This work also revealed that the hemocompatible performance was contributed by PEGylated PEI but not dopamine, as the poly(dopamine)-coating was shown to induce a high level of fibrinogen adsorption as well as vigorous platelet activation.

Original languageEnglish
Pages (from-to)409-420
Number of pages12
JournalInternational Journal of Polymeric Materials and Polymeric Biomaterials
Volume65
Issue number8
DOIs
StatePublished - 23 May 2016

Keywords

  • Bio-inspired coating
  • PEGylatedpoly (ethyleneimine)
  • hemocompatibility
  • material versatility
  • thermal-activated self-copolymerization

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