Heart rhythm complexity analysis in patients with inferior ST-elevation myocardial infarction

Shu Yu Tang; Hsi Pin Ma; Chen Lin; Men Tzung Lo; Lian Yu Lin; Tsung Yan Chen; Cho Kai Wu; Jiun Yang Chiang; Jen Kuang Lee; Chi Sheng Hung; Li Yu Daisy Liu; Yu Wei Chiu; Cheng Hsuan Tsai; Yen Tin Lin; Chung Kang Peng; Yen Hung Lin

doi:10.1038/s41598-023-41261-8

Heart rhythm complexity analysis in patients with inferior ST-elevation myocardial infarction

Shu Yu Tang, Hsi Pin Ma, Chen Lin, Men Tzung Lo, Lian Yu Lin, Tsung Yan Chen, Cho Kai Wu, Jiun Yang Chiang, Jen Kuang Lee, Chi Sheng Hung, Li Yu Daisy Liu, Yu Wei Chiu, Cheng Hsuan Tsai, Yen Tin Lin, Chung Kang Peng, Yen Hung Lin

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Abstract

Heart rhythm complexity (HRC), a subtype of heart rate variability (HRV), is an important tool to investigate cardiovascular disease. In this study, we aimed to analyze serial changes in HRV and HRC metrics in patients with inferior ST-elevation myocardial infarction (STEMI) within 1 year postinfarct and explore the association between HRC and postinfarct left ventricular (LV) systolic impairment. We prospectively enrolled 33 inferior STEMI patients and 74 control subjects and analyzed traditional linear HRV and HRC metrics in both groups, including detrended fluctuation analysis (DFA) and multiscale entropy (MSE). We also analyzed follow-up postinfarct echocardiography for 1 year. The STEMI group had significantly lower standard deviation of RR interval (SDNN), and DFAα2 within 7 days postinfarct (acute stage) comparing to control subjects. LF power was consistently higher in STEMI group during follow up. The MSE scale 5 was higher at acute stage comparing to control subjects and had a trend of decrease during 1-year postinfarct. The MSE area under scale 1–5 showed persistently lower than control subjects and progressively decreased during 1-year postinfarct. To predict long-term postinfarct LV systolic impairment, the slope between MSE scale 1 to 5 (slope 1–5) had the best predictive value. MSE slope 1–5 also increased the predictive ability of the linear HRV metrics in both the net reclassification index and integrated discrimination index models. In conclusion, HRC and LV contractility decreased 1 year postinfarct in inferior STEMI patients, and MSE slope 1–5 was a good predictor of postinfarct LV systolic impairment.

Original language	English
Article number	20861
Journal	Scientific Reports
Volume	13
Issue number	1
DOIs	https://doi.org/10.1038/s41598-023-41261-8
State	Published - Dec 2023

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Tang, S. Y., Ma, H. P., Lin, C., Lo, M. T., Lin, L. Y., Chen, T. Y., Wu, C. K., Chiang, J. Y., Lee, J. K., Hung, C. S., Liu, L. Y. D., Chiu, Y. W., Tsai, C. H., Lin, Y. T., Peng, C. K., & Lin, Y. H. (2023). Heart rhythm complexity analysis in patients with inferior ST-elevation myocardial infarction. Scientific Reports, 13(1), Article 20861. https://doi.org/10.1038/s41598-023-41261-8

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title = "Heart rhythm complexity analysis in patients with inferior ST-elevation myocardial infarction",

abstract = "Heart rhythm complexity (HRC), a subtype of heart rate variability (HRV), is an important tool to investigate cardiovascular disease. In this study, we aimed to analyze serial changes in HRV and HRC metrics in patients with inferior ST-elevation myocardial infarction (STEMI) within 1 year postinfarct and explore the association between HRC and postinfarct left ventricular (LV) systolic impairment. We prospectively enrolled 33 inferior STEMI patients and 74 control subjects and analyzed traditional linear HRV and HRC metrics in both groups, including detrended fluctuation analysis (DFA) and multiscale entropy (MSE). We also analyzed follow-up postinfarct echocardiography for 1 year. The STEMI group had significantly lower standard deviation of RR interval (SDNN), and DFAα2 within 7 days postinfarct (acute stage) comparing to control subjects. LF power was consistently higher in STEMI group during follow up. The MSE scale 5 was higher at acute stage comparing to control subjects and had a trend of decrease during 1-year postinfarct. The MSE area under scale 1–5 showed persistently lower than control subjects and progressively decreased during 1-year postinfarct. To predict long-term postinfarct LV systolic impairment, the slope between MSE scale 1 to 5 (slope 1–5) had the best predictive value. MSE slope 1–5 also increased the predictive ability of the linear HRV metrics in both the net reclassification index and integrated discrimination index models. In conclusion, HRC and LV contractility decreased 1 year postinfarct in inferior STEMI patients, and MSE slope 1–5 was a good predictor of postinfarct LV systolic impairment.",

author = "Tang, {Shu Yu} and Ma, {Hsi Pin} and Chen Lin and Lo, {Men Tzung} and Lin, {Lian Yu} and Chen, {Tsung Yan} and Wu, {Cho Kai} and Chiang, {Jiun Yang} and Lee, {Jen Kuang} and Hung, {Chi Sheng} and Liu, {Li Yu Daisy} and Chiu, {Yu Wei} and Tsai, {Cheng Hsuan} and Lin, {Yen Tin} and Peng, {Chung Kang} and Lin, {Yen Hung}",

note = "Publisher Copyright: {\textcopyright} 2023, The Author(s).",

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doi = "10.1038/s41598-023-41261-8",

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T1 - Heart rhythm complexity analysis in patients with inferior ST-elevation myocardial infarction

AU - Tang, Shu Yu

AU - Ma, Hsi Pin

AU - Lin, Chen

AU - Lo, Men Tzung

AU - Lin, Lian Yu

AU - Chen, Tsung Yan

AU - Wu, Cho Kai

AU - Chiang, Jiun Yang

AU - Lee, Jen Kuang

AU - Hung, Chi Sheng

AU - Liu, Li Yu Daisy

AU - Chiu, Yu Wei

AU - Tsai, Cheng Hsuan

AU - Lin, Yen Tin

AU - Peng, Chung Kang

AU - Lin, Yen Hung

PY - 2023/12

Y1 - 2023/12

N2 - Heart rhythm complexity (HRC), a subtype of heart rate variability (HRV), is an important tool to investigate cardiovascular disease. In this study, we aimed to analyze serial changes in HRV and HRC metrics in patients with inferior ST-elevation myocardial infarction (STEMI) within 1 year postinfarct and explore the association between HRC and postinfarct left ventricular (LV) systolic impairment. We prospectively enrolled 33 inferior STEMI patients and 74 control subjects and analyzed traditional linear HRV and HRC metrics in both groups, including detrended fluctuation analysis (DFA) and multiscale entropy (MSE). We also analyzed follow-up postinfarct echocardiography for 1 year. The STEMI group had significantly lower standard deviation of RR interval (SDNN), and DFAα2 within 7 days postinfarct (acute stage) comparing to control subjects. LF power was consistently higher in STEMI group during follow up. The MSE scale 5 was higher at acute stage comparing to control subjects and had a trend of decrease during 1-year postinfarct. The MSE area under scale 1–5 showed persistently lower than control subjects and progressively decreased during 1-year postinfarct. To predict long-term postinfarct LV systolic impairment, the slope between MSE scale 1 to 5 (slope 1–5) had the best predictive value. MSE slope 1–5 also increased the predictive ability of the linear HRV metrics in both the net reclassification index and integrated discrimination index models. In conclusion, HRC and LV contractility decreased 1 year postinfarct in inferior STEMI patients, and MSE slope 1–5 was a good predictor of postinfarct LV systolic impairment.

AB - Heart rhythm complexity (HRC), a subtype of heart rate variability (HRV), is an important tool to investigate cardiovascular disease. In this study, we aimed to analyze serial changes in HRV and HRC metrics in patients with inferior ST-elevation myocardial infarction (STEMI) within 1 year postinfarct and explore the association between HRC and postinfarct left ventricular (LV) systolic impairment. We prospectively enrolled 33 inferior STEMI patients and 74 control subjects and analyzed traditional linear HRV and HRC metrics in both groups, including detrended fluctuation analysis (DFA) and multiscale entropy (MSE). We also analyzed follow-up postinfarct echocardiography for 1 year. The STEMI group had significantly lower standard deviation of RR interval (SDNN), and DFAα2 within 7 days postinfarct (acute stage) comparing to control subjects. LF power was consistently higher in STEMI group during follow up. The MSE scale 5 was higher at acute stage comparing to control subjects and had a trend of decrease during 1-year postinfarct. The MSE area under scale 1–5 showed persistently lower than control subjects and progressively decreased during 1-year postinfarct. To predict long-term postinfarct LV systolic impairment, the slope between MSE scale 1 to 5 (slope 1–5) had the best predictive value. MSE slope 1–5 also increased the predictive ability of the linear HRV metrics in both the net reclassification index and integrated discrimination index models. In conclusion, HRC and LV contractility decreased 1 year postinfarct in inferior STEMI patients, and MSE slope 1–5 was a good predictor of postinfarct LV systolic impairment.

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U2 - 10.1038/s41598-023-41261-8

DO - 10.1038/s41598-023-41261-8

M3 - 期刊論文

C2 - 38012168

AN - SCOPUS:85177887780

SN - 2045-2322

VL - 13

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 20861

ER -

Heart rhythm complexity analysis in patients with inferior ST-elevation myocardial infarction

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