CuCN reacts with RLi and TMPLi (TMP-2,2,6,6-tetramethylpiperidide) to give Gilman-type cuprates R(TMP)CuLi•nL (R = Ph,n = 3,L = THF 2; R = Me,n = 1,L = TMEDA 3). 3 and 3. LiCN have been tested in directed ortho cupration with data suggesting enhanced efficiency for Lipshutz-type 3. LiCN; competition between Lipshutz- and Gilman-type formulations is rationalized by DFT methods.
|Number of pages||4|
|State||Published - 12 Jan 2009|