First-passage time distribution and non-Markovian diffusion dynamics of protein folding

Chi Lun Lee, George Stell, Jin Wang

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

A study was conducted on the kinetics of folding along a locally connected order-parameter path. A generalized fokker-Planck diffusion equation for describing the folding dynamics was used. The effects of a stability gap δε, temperature, and fluctuations of the folding landscape on first-passenger time (FPT) were discussed. It was found that the mean first-passenger time (MFPT) was smaller when the ratio of the energy gap between the native and average non-native states versus the fluctuations on the landscape, δε/Δε was larger.

Original languageEnglish
Pages (from-to)959-968
Number of pages10
JournalJournal of Chemical Physics
Volume118
Issue number2
DOIs
StatePublished - 8 Jan 2003

Fingerprint

Dive into the research topics of 'First-passage time distribution and non-Markovian diffusion dynamics of protein folding'. Together they form a unique fingerprint.

Cite this