Estimation of the benchmark dose for right-censored lifetime data

Yuh Ing Chen, Wen Ming Lin

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

In this paper, we consider estimating the benchmark dose in a dose-response study with right-censored lifetime data, where the benchmark dose is the dose corresponding to a specific benchmark response, which is related to the probability that the lifetime of a subject receiving the dose is too short. Under the Cox or Weibull extension proportional hazards model, simultaneous lower confidence limits on the benchmark dose are developed. We further conduct a Monte Carlo study to investigate the performance of the proposed lower confidence limits. Finally, a real dataset is illustrated to demonstrate the application of the proposed procedures.

Original languageEnglish
Pages (from-to)1514-1531
Number of pages18
JournalCommunications in Statistics - Simulation and Computation
Volume44
Issue number6
DOIs
StatePublished - 3 Jul 2015

Keywords

  • Benchmark dose
  • Extra risk
  • Proportional hazards model
  • Right-censored lifetime
  • Weibull extension distribution

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