Essential core of protein-protein interaction network in escherichia coli

Chen Ching Lin, Hsueh Fen Juan, Jen Tsung Hsiang, Yih Chii Hwang, Hirotada Mori, Hsuan Cheng Huang

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Essential genes are responsible for the viability of an organism. Global protein interaction network analysis provides an effective way to understand the relationships between protein products of genes. By means of large-scale identification of essential genes and protein-protein interactions, we investigated the substructure of the protein interaction network in Escherichia coli and identified all the cliques in the network. Our analysis showed that larger cliques tend to have larger fractions of proteins encoded by essential genes. By merging the maximum clique with overlapping neighboring cliques, we observed a dense core of the protein interaction network in Escherichia coli with significantly higher ratio of essential genes. The protein network of Saccharomyces cerevisiae also shows strong correlation between clique and essentiality, and there exist similar dense clusters with high essentiality. Our results indicated that the observed structure of essential cores might exist in higher organisms and play important roles in their respective protein networks.

Original languageEnglish
Pages (from-to)1925-1931
Number of pages7
JournalJournal of Proteome Research
Volume8
Issue number4
DOIs
StatePublished - 3 Apr 2009

Keywords

  • Clique
  • Escherichia coli
  • Essential gene
  • Protein -protein interaction network

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