Enhancement of DNA hybridization efficiency using photovoltaic effect

Chii Chang Chen; Wei Chu Ku; Sung Kay Chiu; Chi Meng Tzeng

doi:10.1109/CLEOPR.2003.1277271

Enhancement of DNA hybridization efficiency using photovoltaic effect

Chii Chang Chen, Wei Chu Ku, Sung Kay Chiu, Chi Meng Tzeng

Department of Optics and Photonics

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

We present a novel method to enhance the DNA hybridization efficiency by photovoltaic effect. The arrayed microchip is fabricated in a semiconductor wafer coated with metal thin films for immobilizing the probe DNA. Hybridization in between immobilized probe DNAs and fluorescent-labeled target DNA are carried out through the illumination of a laser. Photovoltaic effect induces positive charges on the surface of microchip to attract negatively charged target DNAs down to the hybridization site, results in efficiently enhancing the hybridization rate up to two-order magnitude. Our observation provided cutting-edge solution away from bottleneck of microchip process in heat and time-consuming.

Original language	English
Title of host publication	CLEO/Pacific Rim 2003 - 5th Pacific Rim Conference on Lasers and Electro-Optics
Subtitle of host publication	Photonics Lights Innovation, from Nano-Structures and Devices to Systems and Networks, Proceedings
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	733
Number of pages	1
ISBN (Electronic)	0780377664
DOIs	https://doi.org/10.1109/CLEOPR.2003.1277271
State	Published - 2003
Event	5th Pacific Rim Conference on Lasers and Electro-Optics, CLEO/Pacific Rim 2003 - Taipei, Taiwan Duration: 15 Dec 2003 → 19 Dec 2003

Publication series

Name	Pacific Rim Conference on Lasers and Electro-Optics, CLEO - Technical Digest
Volume	2

Conference

Conference	5th Pacific Rim Conference on Lasers and Electro-Optics, CLEO/Pacific Rim 2003
Country/Territory	Taiwan
City	Taipei
Period	15/12/03 → 19/12/03

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/CLEOPR.2003.1277271

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Chen, C. C., Ku, W. C., Chiu, S. K., & Tzeng, C. M. (2003). Enhancement of DNA hybridization efficiency using photovoltaic effect. In CLEO/Pacific Rim 2003 - 5th Pacific Rim Conference on Lasers and Electro-Optics: Photonics Lights Innovation, from Nano-Structures and Devices to Systems and Networks, Proceedings (pp. 733). Article 1277271 (Pacific Rim Conference on Lasers and Electro-Optics, CLEO - Technical Digest; Vol. 2). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/CLEOPR.2003.1277271

Chen, Chii Chang ; Ku, Wei Chu ; Chiu, Sung Kay et al. / Enhancement of DNA hybridization efficiency using photovoltaic effect. CLEO/Pacific Rim 2003 - 5th Pacific Rim Conference on Lasers and Electro-Optics: Photonics Lights Innovation, from Nano-Structures and Devices to Systems and Networks, Proceedings. Institute of Electrical and Electronics Engineers Inc., 2003. pp. 733 (Pacific Rim Conference on Lasers and Electro-Optics, CLEO - Technical Digest).

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title = "Enhancement of DNA hybridization efficiency using photovoltaic effect",

abstract = "We present a novel method to enhance the DNA hybridization efficiency by photovoltaic effect. The arrayed microchip is fabricated in a semiconductor wafer coated with metal thin films for immobilizing the probe DNA. Hybridization in between immobilized probe DNAs and fluorescent-labeled target DNA are carried out through the illumination of a laser. Photovoltaic effect induces positive charges on the surface of microchip to attract negatively charged target DNAs down to the hybridization site, results in efficiently enhancing the hybridization rate up to two-order magnitude. Our observation provided cutting-edge solution away from bottleneck of microchip process in heat and time-consuming.",

author = "Chen, {Chii Chang} and Ku, {Wei Chu} and Chiu, {Sung Kay} and Tzeng, {Chi Meng}",

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series = "Pacific Rim Conference on Lasers and Electro-Optics, CLEO - Technical Digest",

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Chen, CC, Ku, WC, Chiu, SK & Tzeng, CM 2003, Enhancement of DNA hybridization efficiency using photovoltaic effect. in CLEO/Pacific Rim 2003 - 5th Pacific Rim Conference on Lasers and Electro-Optics: Photonics Lights Innovation, from Nano-Structures and Devices to Systems and Networks, Proceedings., 1277271, Pacific Rim Conference on Lasers and Electro-Optics, CLEO - Technical Digest, vol. 2, Institute of Electrical and Electronics Engineers Inc., pp. 733, 5th Pacific Rim Conference on Lasers and Electro-Optics, CLEO/Pacific Rim 2003, Taipei, Taiwan, 15/12/03. https://doi.org/10.1109/CLEOPR.2003.1277271

Enhancement of DNA hybridization efficiency using photovoltaic effect. / Chen, Chii Chang; Ku, Wei Chu; Chiu, Sung Kay et al.
CLEO/Pacific Rim 2003 - 5th Pacific Rim Conference on Lasers and Electro-Optics: Photonics Lights Innovation, from Nano-Structures and Devices to Systems and Networks, Proceedings. Institute of Electrical and Electronics Engineers Inc., 2003. p. 733 1277271 (Pacific Rim Conference on Lasers and Electro-Optics, CLEO - Technical Digest; Vol. 2).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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N2 - We present a novel method to enhance the DNA hybridization efficiency by photovoltaic effect. The arrayed microchip is fabricated in a semiconductor wafer coated with metal thin films for immobilizing the probe DNA. Hybridization in between immobilized probe DNAs and fluorescent-labeled target DNA are carried out through the illumination of a laser. Photovoltaic effect induces positive charges on the surface of microchip to attract negatively charged target DNAs down to the hybridization site, results in efficiently enhancing the hybridization rate up to two-order magnitude. Our observation provided cutting-edge solution away from bottleneck of microchip process in heat and time-consuming.

AB - We present a novel method to enhance the DNA hybridization efficiency by photovoltaic effect. The arrayed microchip is fabricated in a semiconductor wafer coated with metal thin films for immobilizing the probe DNA. Hybridization in between immobilized probe DNAs and fluorescent-labeled target DNA are carried out through the illumination of a laser. Photovoltaic effect induces positive charges on the surface of microchip to attract negatively charged target DNAs down to the hybridization site, results in efficiently enhancing the hybridization rate up to two-order magnitude. Our observation provided cutting-edge solution away from bottleneck of microchip process in heat and time-consuming.

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Chen CC, Ku WC, Chiu SK, Tzeng CM. Enhancement of DNA hybridization efficiency using photovoltaic effect. In CLEO/Pacific Rim 2003 - 5th Pacific Rim Conference on Lasers and Electro-Optics: Photonics Lights Innovation, from Nano-Structures and Devices to Systems and Networks, Proceedings. Institute of Electrical and Electronics Engineers Inc. 2003. p. 733. 1277271. (Pacific Rim Conference on Lasers and Electro-Optics, CLEO - Technical Digest). doi: 10.1109/CLEOPR.2003.1277271

Enhancement of DNA hybridization efficiency using photovoltaic effect

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