TY - JOUR
T1 - Engineering reaction and crystallization and the impact on filtration, drying, and dissolution behaviors
T2 - The study of acetaminophen (paracetamol) by in-process controls
AU - Lee, Tu
AU - Lin, Hong Yu
AU - Lee, Hung Lin
PY - 2013/9/20
Y1 - 2013/9/20
N2 - Acetaminophen was synthesized by reacting p-aminophenol with acetic anhydride. Overall materials balance was compiled. Three different crystallization paths (i.e., cases I, II, and III) involving various modes in agitation and addition of sodium hydroxide were taken to produce acetaminophen particles with different particle size distributions (PSDs) and polymorphism. The concentration profile of acetaminophen, temperature, and pH values throughout reaction and crystallization were monitored mainly by in-process control (IPC). The rates of nucleation, crystal growth, and agglomeration during crystallization were quantified by the mixed-suspension mixed-product removal (MSMPR) formalism. The average specific cake resistance for filtration, Krischer rate-moisture plot for drying, Carr's index for powder flowability, and dissolution rate for drug delivery of acetaminophen crystals generated in cases I, II, and III were thoroughly studied and compared.
AB - Acetaminophen was synthesized by reacting p-aminophenol with acetic anhydride. Overall materials balance was compiled. Three different crystallization paths (i.e., cases I, II, and III) involving various modes in agitation and addition of sodium hydroxide were taken to produce acetaminophen particles with different particle size distributions (PSDs) and polymorphism. The concentration profile of acetaminophen, temperature, and pH values throughout reaction and crystallization were monitored mainly by in-process control (IPC). The rates of nucleation, crystal growth, and agglomeration during crystallization were quantified by the mixed-suspension mixed-product removal (MSMPR) formalism. The average specific cake resistance for filtration, Krischer rate-moisture plot for drying, Carr's index for powder flowability, and dissolution rate for drug delivery of acetaminophen crystals generated in cases I, II, and III were thoroughly studied and compared.
UR - http://www.scopus.com/inward/record.url?scp=84884599764&partnerID=8YFLogxK
U2 - 10.1021/op400129n
DO - 10.1021/op400129n
M3 - 期刊論文
AN - SCOPUS:84884599764
SN - 1083-6160
VL - 17
SP - 1168
EP - 1178
JO - Organic Process Research and Development
JF - Organic Process Research and Development
IS - 9
ER -