Enantioselective Synthesis of Nabscessin C

Chun Wei Yeh, Chia Chi Feng, Pei Lin Chen, Yi Jhen Jhou, Duen Ren Hou

Research output: Contribution to journalArticlepeer-review


Enantioselective synthesis of nabscessin C (1), an aminocyclitol amide with antimicrobial activity, is reported. Starting from myo-inositol, (+)-nabscessin C was synthesized in 12 isolation steps. Desymmetrization of 2-deoxygenated 4,6-dibenzylinositol was achieved using lipase from porcine pancreas (PPL), and the stereochemistry was established by X-ray crystallography. This method has the potential for synthesizing other cyclitol-derived compounds.

Original languageEnglish
Pages (from-to)13528-13534
Number of pages7
JournalJournal of Organic Chemistry
Issue number19
StatePublished - 6 Oct 2023


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