Enantioselective synthesis of (+)-brevipolide H

Ching Nung Chen, Duen Ren Hou

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The enantioselective synthesis of natural brevipolide H is reported for the first time. By way of Sharpless epoxidation of penta-1,4-dien-3-ol, both enantiomerically pure epoxides were converted to the corresponding olefins for cross metathesis. Subsequent transformations, including epoxide ring opening, esterifications, cyclopropanation, oxidation and ring-closing metathesis, provided the target molecule. This synthesis successfully addresses previous shortcomings in preparing brevipolides.

Original languageEnglish
Pages (from-to)6762-6768
Number of pages7
JournalOrganic and Biomolecular Chemistry
Issue number28
StatePublished - 2016


Dive into the research topics of 'Enantioselective synthesis of (+)-brevipolide H'. Together they form a unique fingerprint.

Cite this