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Abstract
The enantioselective synthesis of natural brevipolide H is reported for the first time. By way of Sharpless epoxidation of penta-1,4-dien-3-ol, both enantiomerically pure epoxides were converted to the corresponding olefins for cross metathesis. Subsequent transformations, including epoxide ring opening, esterifications, cyclopropanation, oxidation and ring-closing metathesis, provided the target molecule. This synthesis successfully addresses previous shortcomings in preparing brevipolides.
Original language | English |
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Pages (from-to) | 6762-6768 |
Number of pages | 7 |
Journal | Organic and Biomolecular Chemistry |
Volume | 14 |
Issue number | 28 |
DOIs | |
State | Published - 2016 |
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