Electrowetting on nanofilament silicon for matrix-free laser desorption/ionization mass spectrometry

C. W. Tsao, P. Kumar, J. Liu, C. F. Kung, C. C. Chang, D. L. DeVoe

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

Matrix-free laser desorption/ionization mass spectrometry (LDI-MS) using nanofilament Si substrates combined with electrowetting is demonstrated for high-sensitivity analysis of small molecules such as low molecular weight peptides. Individual peptides have been measured with a detection limit of 12 amol, and peptide mass fingerprinting is achieved from tryptic digests of BSA with loadings as low as 150 amol.

Original languageEnglish
Title of host publicationProceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
EditorsJean-Louis Viovy, Patrick Tabeling, Stephanie Descroix, Laurent Malaquin
PublisherChemical and Biological Microsystems Society
Pages640-642
Number of pages3
ISBN (Electronic)9780979806407
StatePublished - 2007
Event11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 - Paris, France
Duration: 7 Oct 200711 Oct 2007

Publication series

NameProceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007

Conference

Conference11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
Country/TerritoryFrance
CityParis
Period7/10/0711/10/07

Keywords

  • Electrowetting
  • MALDI-MS
  • Nanofilament

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