Effect of extracellular calcium concentration on controlling cardiac alternans

Shiuan Ni Liang, Pik Yin Lai

Research output: Contribution to journalConference articlepeer-review


Cardiac alternans may lead to life-threatening arrhythmias or sudden cardiac death. Thus, finding an effective method to suppress alternans is crucial. In this paper, we demonstrate that the time needed to control cardiac alternans induced by rapid pacing using the T+T-feedback control can be dramatically shortened if the extracellular calcium concentration is lowered by a very small amount when the control is turned on. Numerical simulations are performed on the Hund-Rudy dynamic (HRd) model for single cell. Since controlling alternans is important as it can be a precursor of sudden cardiac death, the results of our research may have important clinical implications and will lead to the development of a better control scheme for alternans or a smart defibrillator.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalComputing in Cardiology
StatePublished - 2017
Event44th Computing in Cardiology Conference, CinC 2017 - Rennes, France
Duration: 24 Sep 201727 Sep 2017


Dive into the research topics of 'Effect of extracellular calcium concentration on controlling cardiac alternans'. Together they form a unique fingerprint.

Cite this