The plasma bubble with dust particle depletion can be generated by a nano-second laser pulse focused on one of the dust particles suspended in a strongly coupled dusty plasma liquid. The bubble dynamics at different time scales, including the initial forming and later traveling stages are investigated. In the first stage, dust particles are pushed outward by the outward ion flow associated with the plume generated by the more intensed plasma. The bubble then travels downward at a speed about 60 mm/s associated with a surrounding dipole-like dust flow field. Two bubbles can also be simultaneously generated at different locations by separated laser pulses to study their interactions. Strong coupling is observed between two vertical bubbles. However, two horizontal bubbles are weakly coupled. The possible mechanism is discussed.