Drug-carrier screening on a chip

Tu Lee, Jia Lee

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

In this article, the authors discuss the development of a rapid screening technology based on the integration of spin-on and optical microscopy. This method was tested on four solid dispersion systems, and the spin-on films of each of these systems with various drug-carrier ratios at 25°C were examined by optical microscopy. The results of these experiments showed that drug-carrier screening on a chip had a fast solvent-removal rate by spinning (3-10 s) and a short image-acquisition time by optical microscopy (1-2 min), thereby proving this approach to be suitable for the accelerated development of new solid dispersion materials.

Original languageEnglish
Pages (from-to)40-48
Number of pages9
JournalPharmaceutical Technology North America
Volume27
Issue number1
StatePublished - 1 Jan 2003

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