In this article, the authors discuss the development of a rapid screening technology based on the integration of spin-on and optical microscopy. This method was tested on four solid dispersion systems, and the spin-on films of each of these systems with various drug-carrier ratios at 25°C were examined by optical microscopy. The results of these experiments showed that drug-carrier screening on a chip had a fast solvent-removal rate by spinning (3-10 s) and a short image-acquisition time by optical microscopy (1-2 min), thereby proving this approach to be suitable for the accelerated development of new solid dispersion materials.
|Number of pages||9|
|Journal||Pharmaceutical Technology North America|
|State||Published - 1 Jan 2003|