Direct Acetoxylation of Arenes

Thi Anh Hong Nguyen, Duen Ren Hou

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Acetoxylation of arenes is an important reaction and an unmet need in chemistry. We report a metal-free, direct acetoxylation reaction using sodium nitrate under an anhydrous environment of trifluoroacetic acid, acetic acid, and acetic anhydride. Arenes (31 examples), with oxidation potentials (Eox, in V vs SCE) lower than benzene (2.48 V), were acetoxylated with good yields and regioselectivity. A stepwise, single electron-transfer mechanism is proposed.

Original languageEnglish
Pages (from-to)8127-8131
Number of pages5
JournalOrganic Letters
Issue number21
StatePublished - 5 Nov 2021


Dive into the research topics of 'Direct Acetoxylation of Arenes'. Together they form a unique fingerprint.

Cite this