Diffusion dynamics, moments, and distribution of first-passage time on the protein-folding energy landscape, with applications to single molecules

Chi Lun Lee, Chien Ting Lin, George Stell, Jin Wang

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

We study the dynamics of protein folding via statistical energy-landscape theory. In particular, we concentrate on the local-connectivity case with the folding progress described by the fraction of native conformations. We found that the first passage-time (FPT) distribution undergoes a dynamic transition at a temperature below which the FPT distribution develops a power-law tail, a signature of the intermittent nonexponential kinetic phenomena for the folding dynamics. Possible applications to single-molecule dynamics experiments are discussed.

Original languageEnglish
Pages (from-to)5
Number of pages1
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume67
Issue number4
DOIs
StatePublished - 2003

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