TY - JOUR
T1 - Diffusion dynamics, moments, and distribution of first-passage time on the protein-folding energy landscape, with applications to single molecules
AU - Lee, Chi Lun
AU - Lin, Chien Ting
AU - Stell, George
AU - Wang, Jin
PY - 2003
Y1 - 2003
N2 - We study the dynamics of protein folding via statistical energy-landscape theory. In particular, we concentrate on the local-connectivity case with the folding progress described by the fraction of native conformations. We found that the first passage-time (FPT) distribution undergoes a dynamic transition at a temperature below which the FPT distribution develops a power-law tail, a signature of the intermittent nonexponential kinetic phenomena for the folding dynamics. Possible applications to single-molecule dynamics experiments are discussed.
AB - We study the dynamics of protein folding via statistical energy-landscape theory. In particular, we concentrate on the local-connectivity case with the folding progress described by the fraction of native conformations. We found that the first passage-time (FPT) distribution undergoes a dynamic transition at a temperature below which the FPT distribution develops a power-law tail, a signature of the intermittent nonexponential kinetic phenomena for the folding dynamics. Possible applications to single-molecule dynamics experiments are discussed.
UR - http://www.scopus.com/inward/record.url?scp=85003318612&partnerID=8YFLogxK
U2 - 10.1103/PhysRevE.67.041905
DO - 10.1103/PhysRevE.67.041905
M3 - 期刊論文
C2 - 12786394
AN - SCOPUS:85003318612
SN - 1063-651X
VL - 67
SP - 5
JO - Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
JF - Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
IS - 4
ER -