Development of capacitance measurement system for human serum albumin detection

J. Z. Tsai; C. J. Chen; J. T. Liu; Y. M. Hsin; W. Y. Chen; K. H. Hsueh

doi:10.1049/el.2010.0234

Development of capacitance measurement system for human serum albumin detection

J. Z. Tsai, C. J. Chen, J. T. Liu, Y. M. Hsin, W. Y. Chen, K. H. Hsueh

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The use of interdigitated electrodes and binding with Cibacron blue F3GA by self-assembly technology, which has high affinity for human serum albumin (HSA), and serves as a receptor for HSA detection, is reported. In preliminary tests, the interdigitated chip measured the impedance of HSA by electrochemical impedance spectroscopy and this result indicated the characteristic frequency of impedance change below 1.1kHz. However, a portable capacitance measurement system made using a standard operational amplifier circuit and AC excitation was applied at 1kHz. The detection result showed a significant linear correlation between HSA concentration (0.1 to 1mg/ml) and output voltage. The regression equation was Y=17.91+323.72X with R²=0.999. This reported study has successfully demonstrated that the capacitive sensor has great potential for applications in HSA detection.

Original language	English
Pages (from-to)	678-680
Number of pages	3
Journal	Electronics Letters
Volume	46
Issue number	10
DOIs	https://doi.org/10.1049/el.2010.0234
State	Published - 13 May 2010

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title = "Development of capacitance measurement system for human serum albumin detection",

abstract = "The use of interdigitated electrodes and binding with Cibacron blue F3GA by self-assembly technology, which has high affinity for human serum albumin (HSA), and serves as a receptor for HSA detection, is reported. In preliminary tests, the interdigitated chip measured the impedance of HSA by electrochemical impedance spectroscopy and this result indicated the characteristic frequency of impedance change below 1.1kHz. However, a portable capacitance measurement system made using a standard operational amplifier circuit and AC excitation was applied at 1kHz. The detection result showed a significant linear correlation between HSA concentration (0.1 to 1mg/ml) and output voltage. The regression equation was Y=17.91+323.72X with R2=0.999. This reported study has successfully demonstrated that the capacitive sensor has great potential for applications in HSA detection.",

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T1 - Development of capacitance measurement system for human serum albumin detection

AU - Tsai, J. Z.

AU - Chen, C. J.

AU - Liu, J. T.

AU - Hsin, Y. M.

AU - Chen, W. Y.

AU - Hsueh, K. H.

PY - 2010/5/13

Y1 - 2010/5/13

N2 - The use of interdigitated electrodes and binding with Cibacron blue F3GA by self-assembly technology, which has high affinity for human serum albumin (HSA), and serves as a receptor for HSA detection, is reported. In preliminary tests, the interdigitated chip measured the impedance of HSA by electrochemical impedance spectroscopy and this result indicated the characteristic frequency of impedance change below 1.1kHz. However, a portable capacitance measurement system made using a standard operational amplifier circuit and AC excitation was applied at 1kHz. The detection result showed a significant linear correlation between HSA concentration (0.1 to 1mg/ml) and output voltage. The regression equation was Y=17.91+323.72X with R2=0.999. This reported study has successfully demonstrated that the capacitive sensor has great potential for applications in HSA detection.

AB - The use of interdigitated electrodes and binding with Cibacron blue F3GA by self-assembly technology, which has high affinity for human serum albumin (HSA), and serves as a receptor for HSA detection, is reported. In preliminary tests, the interdigitated chip measured the impedance of HSA by electrochemical impedance spectroscopy and this result indicated the characteristic frequency of impedance change below 1.1kHz. However, a portable capacitance measurement system made using a standard operational amplifier circuit and AC excitation was applied at 1kHz. The detection result showed a significant linear correlation between HSA concentration (0.1 to 1mg/ml) and output voltage. The regression equation was Y=17.91+323.72X with R2=0.999. This reported study has successfully demonstrated that the capacitive sensor has great potential for applications in HSA detection.

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Development of capacitance measurement system for human serum albumin detection

Abstract

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