Development of a molecular imprinting thick film electrochemical sensor for cholesterol detection

Lawrence C.S. Chou, Chung Chiun Liu

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

A combined molecular imprinting and thick film electrochemical sensor for cholesterol concentration detection had been developed. The ferro-ferric cyanide coupled redox reaction was used as the means to quantify the cholesterol presented in the test medium. This electrochemical sensor employed a modified gold working electrode, a platinum counter electrode and an Ag/AgCl reference electrode. The alkanethiol was used to form the self-assembled monolayer (SAM) on the gold working electrode. The SAM was then used with the cholesterol as the template forming the molecular imprinting layer. This sensor prototype could detect cholesterol concentrations between 66 and 700 nM and only a 1 μL of the sample volume was required.

Original languageEnglish
Pages (from-to)204-208
Number of pages5
JournalSensors and Actuators, B: Chemical
Volume110
Issue number2
DOIs
StatePublished - 14 Oct 2005

Keywords

  • Cholesterol detection
  • Molecular imprinting
  • Thick film sensor

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