Determination of estrogenic nonylphenol and bisphenol A in river water by solid-phase extraction and gas chromatography-mass spectrometry

Wang Hsien Ding, Chien Yi Wu

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39 Scopus citations

Abstract

A simple and sensitive method is presented for the analysis of nonylphenol (NP) and bisphenol A (BPA), two well known hormonally active agents (HAAs), in the samples of river water. The method involves extraction of the sample by a graphitized carbon black (GCB) solid-phase extraction, and determination by an ion-trap gas chromatography-mass spectrometry (GC-MS). The large-volume injection technique provides high precision and sensitivity for NP and BPA, to quantitation at < 0.05 μg/L in 200 mL of water samples. Recovery of NP and BPA in spiked water samples ranged from 80% to 85%. Relative standard deviations (RSD) of replicate analyses ranged from 1.6% to 6.9%. The concentrations of NP in rivers were in the range between 0.4 to 2.4 μg/L, which were below the threshold concentration (10 μg/L) for vitellogenin induction in fish, but 78% of water samples from five rivers exceeded the predicted-no-effect concentration (PNEC) of 0.7 μg/L as proposed recently. The concentrations of BPA ranged from < 0.05 μg/L to 3.0 μg/L, which all were below the PNEC of 64 μg/L.

Original languageEnglish
Pages (from-to)1155-1160
Number of pages6
JournalJournal of the Chinese Chemical Society
Volume47
Issue number5
DOIs
StatePublished - 2000

Keywords

  • Bisphenol A
  • Environmental hormones
  • Gas chromatographymass spectrometry
  • Nonylphenol
  • Solid-phase extraction

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