Design and Application of Metal Organic Framework ZIF-90-ZnO-MoS2Nanohybrid for an Integrated Electrochemical Liquid Biopsy

Yuan Zhang, Hao Zhu, Zi Ying, Xinghua Gao, Wei Chen, Yueping Zhan, Lingyan Feng, Chung Chiun Liu, Yifan Dai

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Limited healthcare capacity highlights the needs of integrated sensing systems for personalized health-monitoring. However, only limited sensors can be employed for point-of-care applications, emphasizing the lack of a generalizable sensing platform. Here, we report a metal organic framework (MOF) ZIF-90-ZnO-MoS2 nanohybrid-based integrated electrochemical liquid biopsy (ELB) platform capable of direct profiling cancer exosomes from blood. Using a bottom-up approach for sensor design, a series of critical sensing functions is considered and encoded into the MOF material interface by programming the material with different chemical and structural features. The MOF-based ELB platform is able to achieve one-step sensor fabrication, target isolation, nonfouling and high-sensitivity sensing, direct signal transduction, and multiplexed detection. We demonstrated the capability of the designed sensing system on differentiating cancerous groups from healthy controls by analyzing clinical samples from lung cancer patients, providing a generalizable sensing platform.

Original languageEnglish
Pages (from-to)6833-6840
Number of pages8
JournalNano Letters
Volume22
Issue number16
DOIs
StatePublished - 24 Aug 2022

Keywords

  • electrochemical liquid biopsy
  • integrated sensor
  • metal organic framework
  • point-of-care cancer diagnosis
  • rational material design for electrochemical immunosensor

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