Dependence of third-harmonic-generation on melanin concentration in solution

Tung Yu Su, Chien Sheng Liao, Chih Yuan Yang, Zong Yan Zhuo, Szu Yu Chen, Shi Wei Chu

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

In this study, we performed theoretical analysis and experimental measurement of third harmonic generation (THG) in melanin solution with different concentrations. As predicted by theory, only THG at glass/solution interface was observed due to Guoy phase shift effect. We have shown that this interfacial THG intensity is strongly affected by index matching condition between the two media, leading to minimal THG at a certain melanin concentration. By fitting the dependence of THG intensity versus melanin concentration, linear and nonlinear electric susceptibilities of melanin are obtained, providing a valuable tool to characterize optical properties of biological molecules.

Original languageEnglish
Title of host publicationMultiphoton Microscopy in the Biomedical Sciences XI
DOIs
StatePublished - 2011
EventMultiphoton Microscopy in the Biomedical Sciences XI - San Francisco, CA, United States
Duration: 23 Jan 201125 Jan 2011

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7903
ISSN (Print)1605-7422

Conference

ConferenceMultiphoton Microscopy in the Biomedical Sciences XI
Country/TerritoryUnited States
CitySan Francisco, CA
Period23/01/1125/01/11

Keywords

  • 3D microscopy
  • Melanin
  • Nonlinear susceptibility

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