Cytotoxicity of Postmodified Zeolitic Imidazolate Framework-90 (ZIF-90) Nanocrystals: Correlation between Functionality and Toxicity

Chia I. Yen, Szu Mam Liu, Wei Shang Lo, Jhe Wei Wu, Yi Hsin Liu, Rong Jie Chein, Renqiang Yang, Kevin C.W. Wu, Jih Ru Hwu, Nianhan Ma, Fa Kuen Shieh

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36 Scopus citations

Abstract

Using a simple method, the aldehyde groups of zeolitic imidazolate framework-90 (ZIF-90) nanocrystals were converted into carboxyl, amino, and thiol groups, without affecting the integrity of the framework. Notably, for the first time, correlations between functionality and cytotoxicity are also demonstrated via in vitro cytotoxicity assays. The positive charged aminated-ZIF-90 presumably results in either perturbation of cell membrane, more efficient cell uptake, or both. Therefore, the half-maximal effective (EC50) concentration of aminated-ZIF-90 has a higher cytotoxicity of about 30 μg mL-1. Supermodification: ZIF-90 (zeolitic imidazolate framework-90) nanocrystals were substituted with carboxyl, amino, and thiol groups without affecting framework integrity. In vitro cytotoxicity assays reveals that the positively charged aminated ZIF-90 presumably results in perturbation of cell membrane and/or more efficient cell uptake. The half-maximal effective (EC50) concentration of aminated-ZIF-90 has a higher cytotoxicity (ca. 30 μg mL-1).

Original languageEnglish
Pages (from-to)2925-2929
Number of pages5
JournalChemistry - A European Journal
Volume22
Issue number9
DOIs
StatePublished - 24 Feb 2016

Keywords

  • cytotoxicity
  • drug carriers
  • metal-organic frameworks
  • post-modification
  • ZIF-90

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