Cysteine-capped hydrogels incorporating copper as effective antimicrobial materials against methicillin-resistant staphylococcus aureus

John Jackson Yang, Yung Chi Huang, Tsung Hsien Chuang, Deron Raymond Herr, Ming Fa Hsieh, Chun Jen Huang, Chun Ming Huang

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Methicillin-resistant Staphylococcus aureus (S. aureus) (MRSA) has become an alarming threat to public health, and infected soft tissue. Antibiotics are commonly used to treat skin infection with MRSA, but the inappropriate use of antibiotics runs a considerable risk of generating resistant S. aureus. In this study, we created a cysteine-capped hydrogel able to absorb and release copper, an ion with the capability of suppressing the growth of USA300, a community-acquired MRSA. The results of analysis of Fourier transform infrared spectroscopy (FTIR) revealed the binding of copper to a cysteine-capped hydrogel. The topical application of a cysteine-capped hydrogel binding with copper on USA300-infected skin wounds in the dorsal skin of Institute of Cancer Research (ICR) mice significantly enhanced wound healing, hindered the growth of USA300, and reduced the production of pro-inflammatory macrophage inflammatory protein 2-alpha (MIP-2) cytokine. Our work demonstrates a newly designed hydrogel that conjugates a cysteine molecule for copper binding. The cysteine-capped hydrogel can potentially chelate various antimicrobial metals as a novel wound dressing.

Original languageEnglish
Article number149
JournalMicroorganisms
Volume8
Issue number2
DOIs
StatePublished - Feb 2020

Keywords

  • Antimicrobial
  • Copper
  • Cysteine-capped hydrogels
  • S. Aureus
  • Skin wounds

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