Cyclic block copolymer microchannel fabrication and sealing for microfluidics applications

Chia Yi Yen, Moh Ching O. Chang, Zong Fu Shih, Yi Hsing Lien, Chia Wen Tsao

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


High mechanical rigidity, chemical resistance, and ultraviolet-visible light transmissivity of thermoplastics are attractive characteristics in microfluidics because various biomedical microfluidic devices require solvent, acid, or base manipulation, and optical observation or detection. The cyclic block copolymer (CBC) is a new class of thermoplastics with excellent optical properties, low water absorption, favorable chemical resistance, and low density, which make it ideal for use in polymer microfluidic applications. In the polymer microfabrication process, front-end microchannel fabrication and post-end bonding are critical steps that determine the success of polymer microfluidic devices. In this study, for the first time, we verified the performance of CBC created through front-end microchannel fabrication by applying hot embossing and post-end sealing and bonding, and using thermal fusion and ultraviolet (UV)/ozone surface-assist bonding methods. Two grades of CBC were evaluated and compared with two commonly used cyclic olefin polymers, cyclic olefin copolymers (COC), and cyclic olefin polymers (COP). The results indicated that CBCs provided favorable pattern transfer (>99%) efficiency and high bonding strength in microchannel fabrication and bonding procedures, which is ideal for use in microfluidics.

Original languageEnglish
Article number49
Issue number3
StatePublished - Sep 2018


  • Cyclic block copolymer
  • Hot embossing
  • Microchannel
  • Polymer microfluidics
  • Thermal bonding
  • UV/ozone bonding


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