CRABP2 Is Associated with Thyroid Cancer Recurrence and Promotes Invasion via the Integrin/FAK/AKT Pathway

Chien Liang Liu, Yi Chiung Hsu, Chi Yu Kuo, Jie Yang Jhuang, Ying Syuan Li, Shih Ping Cheng

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Cellular retinoic acid-binding protein 2 (CRABP2) participates in retinoid partitioning between different nuclear receptors. Recently, we identified that CRABP2 is one of the progression-associated genes in thyroid cancer. To explore the prognostic and functional significance of CRABP2, immunohistochemical analysis was performed in thyroid tissues and neoplasms. Overexpression of CRABP2 was observed in malignant thyroid neoplasms but not in benign thyroid lesions. CRABP2 expression was an independent predictive factor for recurrence-free survival in patients with differentiated thyroid cancer. Knockdown of CRABP2 reduced the sensitivity of thyroid cancer cells to retinoic acid. Importantly, CRABP2 expression in thyroid cancer cells was associated with epithelial-mesenchymal transition properties, including anoikis resistance, migration, and invasion capacity. Furthermore, invasion promoted by CRABP2 was mediated at least partly by the integrin/focal adhesion kinase/AKT pathway. In summary, CRABP2 expression is upregulated in thyroid cancer with adverse prognostic implications. The invasion-stimulating effects appear independent of canonical retinoic acid signaling and may serve as a potential therapeutic target.

Original languageEnglish
Article numberbqac171
JournalEndocrinology
Volume163
Issue number12
DOIs
StatePublished - 1 Dec 2022

Keywords

  • cellular retinoic acid-binding protein 2
  • epithelial-mesenchymal transition
  • integrin
  • thyroid cancer

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