@article{ce60204f6aba4a7c9ae433957e934425,
title = "Coumarins hinged directly on benzimidazoles and their ribofuranosides to inhibit hepatitis C virus",
abstract = "A new compound library that contained 20 hinged benzimidazole-coumarin hybrids and their β-d-ribofuranosides was established. The anti-hepatitis C virus (HCV) activity of all novel coumarin derivatives, which were obtained by use of organic synthetic methods, was tested. Two of these hybrids exhibited appealing EC50 values of as low as 3.0 and 5.5 μM. The best selectivity index was 14. The incorporation of a d-ribofuranose into the hinged hybrids provided the corresponding nucleosides with the β configuration, one of which inhibited HCV replication with an EC50 value of 20 μM. Additionally, the structure-activity relationship is elucidated on the basis of the functional groups that were attached to the nuclei of benzimidazole, coumarin, and ribofuranose of the hybrids.",
keywords = "Anti-HCV, Benzimidazole, Coumarin, Hinged hybride, Ribofuranoside",
author = "Tsay, {Shwu Chen} and Hwu, {Jih Ru} and Raghunath Singha and Huang, {Wen Chieh} and Chang, {Yung Hsiung} and Hsu, {Ming Hua} and Shieh, {Fa Kuen} and Lin, {Chun Cheng} and Hwang, {Kuo Chu} and Horng, {Jia Cherng} and {De Clercq}, Erik and Inge Vliegen and Johan Neyts",
note = "Funding Information: The authors are grateful to the National Science Council (NSC 101-2923-I-008-001 ), National Central University ( 101G918 ), National Tsing Hua University (grants nos. 102N2011E1 ), and Ministry of Education of the R.O.C., Taiwan (grants nos. 102N2018E1 ) for their financial support. The work in Leuven was supported by the European Commission SILVER project the 7th Framework Programme as Cooperation Project Grant Agreement (No. 260644 ). Mr. Ted Knoy is appreciated for his editorial assistance. ",
year = "2013",
doi = "10.1016/j.ejmech.2013.02.008",
language = "???core.languages.en_GB???",
volume = "63",
pages = "290--298",
journal = "European Journal of Medicinal Chemistry",
issn = "0223-5234",
}