Continuous preparation of 1:1 haloperidol-maleic acid salt by a novel solvent-free method using a twin screw melt extruder

Chemical Compounds

• Acid Salt 82%
• Extrusion 67%
• Haloperidol 57%
• Maleic Acid 49%
• Crystallization 38%
• Hydrate 26%
• Pharmaceutical 20%
• Enthalpy of Melting 18%
• Neutralization Reaction 17%
• Ethyl Acetate 12%
• Optical Microscopy 12%
• Organic Solvent 10%
• Single Crystal X-Ray Diffraction 10%
• Sorption 9%
• Solubility 8%
• Volume 8%
• Mixture 6%

Medicine & Life Sciences

• maleic acid 100%
• Haloperidol 76%
• Salts 61%
• Crystallization 26%
• Solubility 16%
• Temperature 7%
• ethyl acetate 6%
• X-Ray Diffraction 6%
• Proton Magnetic Resonance Spectroscopy 6%
• Heating 5%
• Freezing 5%
• Microscopy 4%
• Pharmaceutical Preparations 4%
• Hot Temperature 4%
• Acids 4%
• Water 3%