Construction of a prediction model for nephropathy among obese patients using genetic and clinical features

Guan Mau Huang, Yi Cheng Chen, Julia Tzu Ya Weng

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Obesity is a complex disease arising from an excessive accumulation of body fat which leads to various complications such as diabetes, hypertension, and renal diseases. The growing prevalence of obesity is also becoming a major risk factor for nephropathy. When patients are diagnosed with nephropathy, their progression towards renal failure is usually inevitable. Therefore, a prediction tool will help medical doctors identify patients with a higher risk of developing nephropathy and implement early treatment or prevention. In this study, we attempted to construct a diagnostic support system for nephropathy using clinical and genetic traits. Our results show that prediction models involving the use of both genetic and clinical features yielded the best classification performance. Our finding is in accordance with the complex nature of obesity-related nephropathy and support the notion of using genetic traits to design a personalized diagnostic model.

Original languageEnglish
Title of host publicationTrends and Applications in Knowledge Discovery and Data Mining, PAKDD 2015 Workshops
Subtitle of host publicationBigPMA, VLSP, QIMIE, DAEBH, Revised Selected Papers
EditorsXiao-Li Li, David Cheung, Ee-Peng Lim, Hiroshi Motoda, Tu-Bao Ho, Tru Cao, Zhi-Hua Zhou
PublisherSpringer Verlag
Pages104-112
Number of pages9
ISBN (Print)9783319256597
DOIs
StatePublished - 2015
Event19th Pacific-Asia Conference on Knowledge Discovery and Data Mining, PAKDD 2015 - Ho Chi Minh City, Viet Nam
Duration: 19 May 201519 May 2015

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume9441
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference19th Pacific-Asia Conference on Knowledge Discovery and Data Mining, PAKDD 2015
Country/TerritoryViet Nam
CityHo Chi Minh City
Period19/05/1519/05/15

Keywords

  • Nephropathy
  • Obesity
  • Personalized diagnostic support system
  • Prediction

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