Confidence bands for the difference between two median survival times as a function of covariates

Yuh Ing Chen, Yu Mei Chang, Jen Yu Lee

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

In this paper, the estimation of the difference between two median survival times is considered when two treatment groups of right-censored data and the associated covariates are available. To identify the possible range of covariates over which the two treatments would produce different median survival times, two confidence bands for the difference as a function of the covariates are proposed under the stratified and treatment-specific Cox models, respectively. The results of a simulation study indicate that the latter generally maintains its confidence level and the former holds its confidence level and preserves a narrower width when the two treatments satisfy the stratified Cox model. An application of the proposed confidence bands is finally illustrated with a data set in a two-arm lung cancer study.

Original languageEnglish
Pages (from-to)97-118
Number of pages22
JournalLifetime Data Analysis
Volume21
Issue number1
DOIs
StatePublished - Jan 2013

Keywords

  • Confidence band
  • Median survival time
  • Right-censored data
  • Stratified Cox model
  • Treatment-specific Cox model

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