Comparison of topical mupirocin and gentamicin in the prevention of peritoneal dialysis-related infections: A systematic review and meta-analysis

Chia Chi Tsai, Po Sheng Yang, Chien Liang Liu, Chih Jen Wu, Yi Chiung Hsu, Shih Ping Cheng

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Background Topical antibiotics have been shown to reduce exit-site infection and peritonitis. The aim of this study was to compare infection rates between mupirocin and gentamicin. Methods Multiple comprehensive databases were searched systematically to include relevant randomized controlled trials and observational studies. Pooled risk ratios (RRs) and 95% confidence intervals were calculated for the incidences of exit-site infection and peritonitis. Results Seven studies (mupirocin group n = 458, gentamicin group n = 448) were analyzed for exit-site infection. The risk of gram-positive exit-site infection was similar between the groups. Gram-negative exit-site infection rate was higher in the mupirocin group (RR = 2.125, P = 0.037). Six studies were assessed the peritonitis risk. There was no difference in the gram-positive and -negative peritonitis rate. Conclusions Topical use of gentamicin is associated with fewer exit-site infections caused by gram-negative organisms. Gentamicin has comparable efficacy to mupirocin for peritonitis and gram-positive exit-site infection.

Original languageEnglish
Pages (from-to)179-185
Number of pages7
JournalAmerican Journal of Surgery
Volume215
Issue number1
DOIs
StatePublished - Jan 2018

Keywords

  • Exit-site infection
  • Gentamicin
  • Mupirocin
  • Peritoneal dialysis
  • Peritonitis

Fingerprint

Dive into the research topics of 'Comparison of topical mupirocin and gentamicin in the prevention of peritoneal dialysis-related infections: A systematic review and meta-analysis'. Together they form a unique fingerprint.

Cite this