Common-path phase-shift interferometry surface plasmon resonance imaging system

Y. D. Su, S. J. Chen, T. L. Yeh

Research output: Contribution to journalArticlepeer-review

91 Scopus citations


Surface plasmon resonance (SPR) and common-path phase-shift interferometry (PSI) techniques are integrated in a biosensing imaging system for measuring the two-dimensional spatial phase variation caused by biomolecular interactions on a sensing chip without the need for additional labeling. The common-path PSI technique has the advantage of long-term stability, even when it is subjected to external disturbances. Hence the system meets the requirements of the real-time kinetic studies involved in biomolecular interaction analysis. The proposed SPR–PSI imaging system demonstrates a detection limit of a 2 × 10−7 refractiveindex change, a long-term phase stability of 2.5 × 10−4 π rms for 4 h, and a spatial phase resolution of 10−3 π with a lateral resolution of 100 ³m.

Original languageEnglish
Pages (from-to)1488-1490
Number of pages3
JournalOptics Letters
Issue number12
StatePublished - 2005


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