Cognitive and neuropsychiatric correlates of EEG dynamic complexity in patients with Alzheimer's disease

Albert C. Yang, Shuu Jiun Wang, Kuan Lin Lai, Chia Fen Tsai, Cheng Hung Yang, Jen Ping Hwang, Men Tzung Lo, Norden E. Huang, Chung Kang Peng, Jong Ling Fuh

Research output: Contribution to journalArticlepeer-review

100 Scopus citations


This study assessed the utility of multiscale entropy (MSE), a complexity analysis of biological signals, to identify changes in dynamics of surface electroencephalogram (EEG) in patients with Alzheimer's disease (AD) that was correlated to cognitive and behavioral dysfunction. A total of 108 AD patients were recruited and their digital EEG recordings were analyzed using MSE methods. We investigate the appropriate parameters and time scale factors for MSE calculation from EEG signals. We then assessed the within-subject consistency of MSE measures in different EEG epochs and correlations of MSE measures to cognitive and neuropsychiatric symptoms of AD patients. Increased severity of AD was associated with decreased MSE complexity as measured by short-time scales, and with increased MSE complexity as measured by long-time scales. MSE complexity in EEGs of the temporal and occipitoparietal electrodes correlated significantly with cognitive function. MSE complexity of EEGs in various brain areas was also correlated to subdomains of neuropsychiatric symptoms. MSE analysis revealed abnormal EEG complexity across short- and long-time scales that were correlated to cognitive and neuropsychiatric assessments. The MSE-based EEG complexity analysis may provide a simple and cost-effective method to quantify the severity of cognitive and neuropsychiatric symptoms in AD patients.

Original languageEnglish
Pages (from-to)52-61
Number of pages10
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
StatePublished - 2 Dec 2013


  • Alzheimer's disease
  • Complexity
  • Electroencephalogram
  • Multiscale entropy


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