Co-overexpression of cyclooxygenase-2 and microsomal prostaglandin e Synthase-1 adversely affects the postoperative survival in non-small cell lung cancer

Yu Chung Wu, Li Jen Su, Hao Wei Wang, Chien Fu Jeff Lin, Wen Hu Hsu, Teh Ying Chou, Chi Ying F. Huang, Chia Li Lu, Chung Tsen Hsueh

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Introduction: Cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase (mPGES)-1 have been found to be overexpressed in non-small cell lung cancer (NSCLC). The aim of this study was to investigate the expression profiles of COX-2 and mPGES-1 and their correlation with the clinical characteristics and survival outcomes in patients with resected NSCLC. Methods/Results: Seventy-nine paired adjacent normal-tumor matched samples were prospectively procured from patients undergoing surgery for NSCLC. The protein levels of COX-2 and mPGES-1 were assessed by Western blot analysis. Overexpression in the tumor sample was defined as more than twofold increase in protein expression compared with the corresponding adjacent normal tissue. Co-overexpression of COX-2 and mPGES-1 were further confirmed by immunohistochemistry. COX-2 was overexpressed in 58% and mPGES-1 in 70% of the tumor samples (p < 0.0001). Co-overexpression of mPGES-1 and COX-2 was noted in 43%, and they were unrelated to each other (p = 0.232). Co-overexpression of both proteins was significantly associated with less tumor differentiation (p = 0.046), tumor size larger than 5 cm (p = 0.038), and worse survival status during the follow-up (p = 0.036). Multivariate analysis showed that in addition to overall stage, co-overexpression of both proteins adversely affected the overall (hazard ratio, 2.40; p = 0.045) and disease-free survivals (hazard ratio, 2.27; p = 0.029). Conclusions: Overexpression of either COX-2 or mPGES-1 is common but unrelated in NSCLC. Co-overexpression of both COX-2 and mPGES-1 adversely affects postoperative overall and disease-free survivals.

Original languageEnglish
Pages (from-to)1167-1174
Number of pages8
JournalJournal of Thoracic Oncology
Volume5
Issue number8
DOIs
StatePublished - Aug 2010

Keywords

  • Cyclooxygenase-2
  • Microsomal prostaglandin E synthase-1
  • Non-small cell lung cancer
  • Survival

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