Chinese herbal medicine compound of flavonoids adjunctive treatment for oral cancer

Yi Chao Huang, Min Yi Sung, Tsung Kun Lin, Chan Yen Kuo, Yi Chiung Hsu

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Oral cancer is a prevalent global issue, with oral squamous cell carcinoma constituting the majority of cases. Standard treatments like surgery, radiotherapy, and chemotherapy are available but may have adverse effects. Molecular gene therapy, focusing on genetic mutations linked to oral cancer, presents a promising alternative.In this study, we evaluated 27 chemotherapeutic drugs and 63 Chinese herbal medicines for their effectiveness, categorized them by their cellular mechanisms, and identified potential adjuvant therapy candidates for oral cancer. Our findings highlight the impact of natural flavonoids on oral cancer cells, inducing apoptosis, and confirming their potential in molecular genetic analysis. In conclusion, the natural compounds present in Chinese herbal medicine, particularly flavonoids, offer a promising avenue to target specific genetic mutations in oral cancer cells. This approach may reduce the risks associated with oral cancer treatment and pave the way for innovative adjuvant therapies.

Original languageEnglish
JournalJournal of the Formosan Medical Association
StateAccepted/In press - 2023


  • Adjuvant treatment
  • Chemotherapy
  • Chinese herbal medicine
  • Flavonoid
  • Oral cancer


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