Chemically modified polysulfone hollow fibers with vinylpyrrolidone having improved blood compatibility

Akon Higuchi, Kazunobu Shirano, Masaharu Harashima, Boo Ok Yoon, Mariko Hara, Mitsuo Hattori, Kazuo Imamura

Research output: Contribution to journalArticlepeer-review

215 Scopus citations

Abstract

Hydrophilic polysulfone membranes (PVP-PSf) were prepared from polysulfone membranes covalently conjugated with polyvinylpyrrolidone (PVP) on the surface. The immobilized amount of vinylpyrrolidone on PVP-PSf membranes was controlled by the amount of vinylpyrrolidone monomer in the reaction solution and the reaction time. The PVP-PSf membranes were found to be the most hydrophilic membranes among the polysulfone and surface-modified polysulfone membranes prepared in this study. This is explained by the long hydrophilic side chain of polyvinylpyrrolidone on the PVP-PSf membranes which contributes to the hydrophilic wiper on the hydrophobic PSf membranes. It was found that PVP-PSf membranes gave lower protein adsorption from a plasma solution than polysulfone and other surface-modified membranes (p<0.01). This is attributed to the hydrophilic surface of the PVP-PSf membranes, because the hydrophilic surface is known to reduce the protein adsorption on the membranes. The PVP-PSf membranes showed a much suppressed number of adhering platelets on the surface than polysulfone and other surface-modified membranes (p<0.01). It is suggested that the hydrophilic surface of the PVP-PSf membranes without ionic groups causes the suppression of platelet adhesion on the PVP-PSf membranes and that the long hydrophilic side chain of polyvinylpyrrolidone on PVP-PSf membranes contributes to the hydrophilic and hemocompatible wipers on the surface of the hydrophobic PSf membranes.

Original languageEnglish
Pages (from-to)2659-2666
Number of pages8
JournalBiomaterials
Volume23
Issue number13
DOIs
StatePublished - 2002

Keywords

  • Blood compatibility
  • Membrane
  • Platelet adhesion
  • Polysulfone
  • Protein adsorption
  • Surface modification

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