@inproceedings{c8b9ad45d1534f3dbbaf88cc654a1a2e,
title = "Cell lysis by low power focused acoustic transducer and investigation of acoustic intensity threshold for cytolysis of various cell lines",
abstract = "This paper reports recent development of micron-sized cell lysis without noticeable acoustic cavitation by a Self Focused Acoustic Transducer (SFAT). Localized cell lysis was obtained with prostate cancer cell lines and breast cancer cell lines by applying various power intensity levels at the transducer's fundamental and 3rd harmonic resonant frequencies (17.3 and 56 MHz, respectively). The cell lysis area was around 100 μm (fundamental) and 50 μm (third harmonic) in diameter. According to the results, the cell lysis area depended on the acoustic-wave frequency, but not on the applied acoustic intensity above the threshold intensity. Also, different cell lines showed varied sensitivity to focused acoustic energy, and had different energy threshold for localized cytolysis.",
keywords = "Cancer, Localized cytolysis, Micro-electro-mechanical-system (MEMS), Self focused acoustic transducer (SFAT)",
author = "Lingtao Wang and Li, {Yi Jia} and Anderson Lin and Chen, {Shih Jui} and Mitchell Gross and Kim, {Eun Sok}",
year = "2011",
language = "???core.languages.en_GB???",
isbn = "9781618395955",
series = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011",
pages = "434--436",
booktitle = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011",
note = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 ; Conference date: 02-10-2011 Through 06-10-2011",
}