CCM111, the water extract of Antrodia cinnamomea, regulates immune-related activity through STAT3 and NF-κB pathways

In Yu Lin, Min Hsiung Pan, Ching Shu Lai, Ting Ting Lin, Chiung Tong Chen, Tao Sheng Chung, Chien Lung Chen, Chen Huan Lin, Wu Chang Chuang, Ming Chung Lee, Ching Che Lin, Nianhan Ma

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Antrodia cinnamomea (AC) exhibits many bioactivities, including anti-inflammatory, anti-cancer, and hepatoprotection activities. Many researchers have studied the functions of the components or fractions of AC, but the functions of the original extractions of AC have not been studied. In addition, the detailed relationship between AC and immune-related signaling pathways is unclear. In this study, we screened the effects of CCM111, which is the extract of AC, on seven immune-related signaling pathways and further investigated whether CCM111 can influence inflammation. Interestingly, our results showed that CCM111 significantly inhibited the IL-6-stimulated STAT3 pathway and the LPS-stimulated NF-κB pathway in macrophages. CCM111 also decreased the phosphorylation of STAT3, Tyk2 and the nuclear translocation of p65. Moreover, CCM111 and F4, a fraction of CCM111, down-regulated nitric oxide (NO) production, the protein levels of iNOS and COX-2, and inflammatory cytokines in macrophage cells. Therefore, our study suggested that CCM111 has the potential to be developed as an effective anti-inflammatory agent.

Original languageEnglish
Article number4862
JournalScientific Reports
Volume7
Issue number1
DOIs
StatePublished - 1 Dec 2017

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