Cardiac alternans reduction by chaotic attractors in T ± ϵ feedback control

Duy Manh Le, Y. T. Lin, Y. H. Yang, Pik Yin Lai, C. K. Chan

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


To achieve control in dynamical systems, one usually avoids the generation of chaos. However, an effective control of an unstable dynamical system can also be practically achieved by deliberately inducing chaos in the system if the induced chaotic attractors are confined in a very small region in phase space. Using nonlinear dynamic analysis of the cardiac restitution model, we reveal that the mechanism of the recently proposed T ± ϵ control for cardiac alternans suppression is due to the confined chaotic attractors so generated. These results are confirmed experimentally by detailed phase-space portrait and transition dynamics measurements in whole heart experiments.

Original languageEnglish
Article number50001
Issue number5
StatePublished - Mar 2017


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